Reply To: IGF-1 LR3 how it would work?
Written by GrayJ on . Posted in
I personally did liked the stuff but that’s only if you are getting good stuff and I say this because as much as I know there is a lot of crappy quality stuff out there. that’s why, if you are really interested in trying out then make sure that it is going to be properly made. Sure there is a patent on it, however its still being made, pretty much like some SARMS out there… very well, if you are interested then here is some information for you that could be of some use I think, I’ve made the research a while back so here’s something pretty important:
Why the peptides that you are planning to use should be made from a recombinant DNA source and not a chemically synthesized source.
So well, I want to bring something up about peptides and peptide quality. I really see a lot of people going the cheap route, however there is a reason that they may be simply wasting their money. this is the reason why I wanted to start a thread about a problem that I think it is going to be realted to the efficacy of the chemically synthesized IGF and most of the other peptides out here in comparison to the recombinant made ones.
From the research I have made I noticed that there are a lot of threads all over there about the IGF 1 and there are other peps that are giving quite some good gains and to be honest, I do feel as if some of it may be bs or the person is just having something known as a ‘placebo effect’, but on the other hand we have other people who can swear that peptides are a total 100% scam and that they are doing absolutely nothing at all (which is then again, not true either)… I believe there is a ‘balance’ between the 2 which means that while it is not anything like a miracle we still cannot call it useless. And while some should think: maybe you’ve got placebo effect? The others might think that there might be a reason why their IGF 1 cycle did not gave them jack shit?! And now, of course.. why that happened?
I personally am thinking that most people are purchasing IGF 1 (for an example of a popular peptide being used) made by some cheap peptide synthesis companies. However, chemical synthesis of the IGF 1 is lacking the correct (proper) disulfide bonds which is causing the proper folding and function in the whole peptide chain. IGF 1 and its many many analogs are requiring 3 disulfide bonds in order to generate the correct folded form of the protein and this can only be accomplished in the body as being naturally produced, or in E. coli bacteria as a recombinant source that is being quite similar to how the HGH is being made (I mean, in the recombinant way).
There’s also insulin which is another one very similar in terms of the structure of the IGF 1 and it is also being inactive and/ or unstable in case is being synthesized chemically, it has to be recombinant made or to be extracted from some biologic source (for those who still don’t know, they were used to extract insulin from bovine and the HGH from cadavers, I know it sounds gross but that’s reality).
Now, when you see that it is made with ‘recombinant DNA’ this only means that it is made in bacteria which is having data input into it and then is being ‘fermented’ create enzymes that is making those intramolecular disulfide bonds so that the protein folds into the right configuration and therefore it has the biological function it is being supposed to have, having the proper amino chain that is NOT being enough and be sure that it is NOT that simple as you may imagine. If you are going to look more into the human clinical trials or current clinical treatments of the patients, they are currently using some of those peptides as a part of a therapy protocol and therefore they are using recombinant DNA made peptides, they are not using the chemically synthesized ones and they are not using them for a really good reason.
You can go on ncbi. nlm. nih. gov (without spaces, I am not sure if we can include links) and search for *Role of native disulfide bonds in the structure and activity of insulin-like growth factor 1: genetic models of protein-folding intermediates.* and click on pubmed article. There you are going to find just one of the many other studies on how actually important the correct bonds are, and not only the structure of them. I recommend reading that one because I really liked the way they wrote it. there is only a little bit to read but it is said very well. And that was written back in 1993!
Anyway, I can say that there are a lot of those cheap peptide sellers out there that seemingly seem to appear every single day for the last couple of years with some extremely, i would even say funnily low prices. Their prices are some ridiculously cheap that they just don’t make absolutely any sense. I mean, they are so cheap that it is a clear sign they are fakes etc. but people still fall for it and buy them. It is pretty much like you see a $50,000 car being sold for $500. You know there’s something wrong with it. that is why, if there is something that does seems to be too good to be true then most likely that is so!
And trust me, there are good reasons as why there are some places that are so cheap in the time there are some other places that are selling ‘seemingly’ the same product but it can cost more than 2 times or even 3 times or more the amount compared to those cheaper places. The saying ‘if it seems to be too good to be true then that’s so’ applies to everything and I also like the saying ‘you are getting what you are paying for’ as that’s also true. I like these as they are both true in most of the cases, or at least they usually are like that… and this is the reason why I wanted to recommend you to do your research first before purchasing anything. And we should think like this the other way around. I didn’t tried to say that you need to go for the most pricey one as just because it is pricey it again doesn’t automatically mean that it is of the best quality, you still need to research the company properly and make sure that you are not overly paying for something. However in case it is really really cheap then if I would be you I would simply avoid due to the fact that the chances of that stuff to be properly made are very low and even close to 0 in such case. Again, you can’t sell something net worth $ 100 for $ 50 no? just my opinion. So please be safe and try to avoid scammers as there is a flooded market of crappy quality made peptides that is coming from China and maybe from everywhere else on this Earth.
What you really want it is the more expensive recombinant DNA made peptides if you really want it to work. Make sure not to get the cheaply made, unstable and largely biologically inactive chemically synthesized peptides. From as much as I saw, there are a lot of people out there that have absolutely no ideas about all of this and this is the reason why I decided to make this thread and hopefully this is going to help you and maybe it will help someone else too. Good luck and all the best!